Haplogroup H (mtDNA) +Search for Videos

haplogroup
H
20,000-25,000 YBP
Southwest Asia+
HV+
H* lineages, H1, H2, H3, H4, H5'36, H6, H7, H8, H9, H10, H11, H12, H13, H14, H15, H16, H18, H19, H20, H22, H23, H24, H25, H26, H28, H29, H31, H32, H33, H34, H35, H37, H38, H39, 16129(H17+H27), 16129(H21+H30)
G2706A, T7028C


In human mitochondrial genetics+, '''haplogroup H''' is a human mitochondrial DNA+ (mtDNA) haplogroup that likely originated in Southwest Asia+ 20,000-25,000 years before present+.

Mitochondrial haplogroup H is a predominantly European haplogroup that originated outside of Europe before the last glacial maximum (LGM). It first expanded in the northern Near East+ and Southern Caucasus+ between 33,000 and 26,000 years ago, and later migrations from Iberia+ suggest it reached Europe before the Last Glacial Maximum+. It has also spread to Siberia+ and inner Asia. Today, about 40% of all mitochondrial lineages in Europe are classified as haplogroup H.

Haplogroup H is a descendant of haplogroup HV+. The Cambridge Reference Sequence+ (CRS), which until recently was the human mitochondrial sequence to which all others were compared, belongs to haplogroup H2a2a1 (human mitochondrial sequences should now be compared with the ancestral Reconstructed Sapiens Reference Sequence (RSRS)). Several independent studies conclude that haplogroup H probably evolved in West Asia+ c. 25,000 years ago. It was carried to Europe by migrations c. 20-25,000 years ago, and spread with population of the southwest of the continent. Its arrival was roughly contemporary with the rise of the Gravettian+ culture. The spread of subclades H1, H3 and the sister haplogroup V+ reflect a second intra-European expansion from the Franco-Cantabrian region+ after the last glacial maximum+, c. 13,000 years ago.

In July 2008 ancient mtDNA from an individual called Paglicci 23+, whose remains were dated to 28,000 years ago and excavated from Paglicci Cave+ (Apulia+, Italy+), were found to be identical to the Cambridge Reference Sequence in HVR1+. This once was believed to indicate haplogroup H, but researchers now recognize that CRS can also appear in U or HV. Haplogroup HV derives from the Haplogroup R0 which in turn derives from haplogroup R is a descendant of macro-haplogroup N like its sibling M, is a descendant of haplogroup L3.

Haplogroup H has also been found among Iberomaurusian+ specimens at the Taforalt+ prehistoric site.

Haplogroup H is the most common mtDNA clade in Europe+. It is found in approximately 41% of native Europeans. The lineage is also common in North Africa+ and the Middle East+.

The majority of the European populations have an overall haplogroup H frequency of 40%–50%. Frequencies decrease in the southeast of the continent, reaching 20% in the Near East and Caucasus, 17% in Iran, and <10% in the Persian Gulf, Northern India and Central Asia+.

Undifferentiated haplogroup H has been found among Palestinians+ (14%), Syrians+ (13.6%), Druze+ (10.6%), Iraqis+ (9.5%), Somalis+ (6.7%), Saudis+ (5.3%-10%), Nubians+ (1.3%), and Yemen+is (0%-13.9%).

Among all these clades, the subhaplogroups H1 and H3 have been subject to a more detailed study and would be associated to the Magdalenian+ expansion from SW Europe c. 13,000 years ago:

H1 encompasses an important fraction of Western European mtDNA, reaching its local peak among contemporary Basques+ (27.8%) and appearing at a high frequency among other Iberians+ and North Africa+ns. Its frequency is above 10% in many other parts of Europe (France, Sardinia, British Isles, Alps, large portions of Eastern Europe), and above 5% in nearly all the continent. Its subclade '''H1b''' is most common in eastern Europe and NW Siberia. So far, the highest frequency of H1 (61%) has been found among the Tuareg+ inhabiting the Fezzan+ region in Libya+.
; Frequencies of haplogroup H1 in the world (Ottoni et al. 2010)
! Region or Population
! H1%
! No. of subjects

| '''Africa'''| |

| Libyan Tuareg|61|129

| Tuareg (West Sahel)|23.3|90

| Berbers (Morocco)|20.2|217

| Morocco|12.2|180

| Berbers (Tunisia)|13.4|276

| Tunisia |10.6|269

| Mozabite|9.8|80

| Siwas (Egypt) |1.1|184

| Western Sahara|14.8|128

| Mauritania|6.9|102

| Senegal |0|100

| Fulani (Chad-Cameroon)|0|186

| Cameroon|0|142

| Chad |0|77

| Buduma (Niger)|0|30

| Nigeria|0|69

| Ethiopia|0|82

| Amhara (Ethiopia)|0|90

| Oromo (Ethiopia)|0|117

| Sierra Leone|0|155

| Guineans (Guiné Bissau)|0|372

| Mali|0|83

| Kikuyu (Kenya)|0|24

| Benin|0|192

| '''Asia'''| |

| Central Asia|0.7|445

| Pakistan|0|100

| Yakuts |1.7|58

| '''Caucasus''' | |

| Caucasus (north) |8.8|68

| Caucasus (south)|2.3|132

| Northwestern Caucasus|4.7|234

| Armenians|2.3|175

| Daghestan|2.5|269

| Georgians|1|193

| Karachay-Balkars|4.4|203

| Ossetians|2.4|296

| '''Europe''' | |

| Andalusia |24.3|103

| Basques (Spain) |27.8|108

| Catalonia|13.9|101

| Galicia|17.7|266

| Pasiegos (Cantabria) |23.5|51

| Portugal|25.5|499

| Spain (miscellaneous) |18.9|132

| Italy (north) |11.5|322

| Italy (center) |6.3|208

| Italy (south)|8.7|206

| Sardinia |17.9|106

| Sicily |10|90

| Finland |18|78

| Volga-Ural Finnic speakers|13.6|125

| Basques (France) |17.5|40

| Béarnaise |14.8|27

| France|12.3|106

| Estonia|16.7|114

| Saami|0|57

| Lithuania|1.7|180

| Hungary |11.3|303

| Czech Republic |10.8|102

| Ukraine|9.9|191

| Poland|9.3|86

| Russia|13.5|312

| Austria|10.6|2487

| Germany|6|100

| Romania|9.4|360

| Netherlands |8.8|34

| Greece (Aegean islands) |1.6|247

| Greece (mainland) |6.3|79

| Macedonia |7.1|252

| Albania|2.9|105

| Turks|3.3|360

| Balkans|5.4|111

| Croatia |8.3|84

| Slovaks|7.6|119

| Slovak (East)|16.8|137

| Slovak (West)|14.2|70

| '''Middle East''' | |

| Arabian Peninsula|0|94

| Arabian Peninsula (incl. Yemen, Oman) |0.8|493

| Druze |3.4|58

| Dubai (United Arab Emirates)|0.4|249

| Iraq|1.9|206

| Jordanians|1.7|173

| Lebanese|4.2|167

| Syrians|0|159

|

H3 is found throughout the whole of Europe and in the Maghreb+ but does not exist in the Far East, and is believed to have originated among Mesolithic hunter-gatherers in south-western Europe between 9 000 and 11 000 years ago. H3 represents the second largest fraction of the H genome after H1 and has a somewhat similar distribution, with peaks in Portugal, Spain, Scandinavia and Finland. It is common in Portugal (12%), Sardinia (11%), Galicia (10%), the Basque country (10%), Ireland (6%), Norway (6%), Hungary (6%) and southwestern France (5%).http://www.eupedia.com/europe/Haplogroup_H_mtDNA.shtml Access date 2015/10/02 Studies have suggested haplogroup H3 is highly protective against AIDS progression.

Example of H3 sub-groups are:
*H3a and H3g, found in north-west Europe.
*H3b and H3k, found in the British Isles and Catalonia
*H3c, found in Western Europe, including among the Basques
*H3h, found throughout northern Europe, but was also found in Cerdic of Wessex+ (519 to 534), King of West Saxons
*H3i found in Ireland and Scotland
*H3j found in Italy
*H3v found especially in Germanic countries
*H3z found in Atlantic Europe


H5 may have evolved in West Asia, where it is most frequent and diverse in the Western Caucasus, but its subclade '''H5a''' has a stronger representation in Europe, though at low levels.U. Roostalu et al, Origin and expansion of haplogroup H, the dominant human mitochondrial DNA lineage in West Eurasia: the Near Eastern and Caucasian perspective, ''Molecular Biology and Evolution'', vol. 24, no. 2 (2007), pp. 436-448.

These haplogroups are somewhat common in Eastern Europe and the Caucasus. They may be the most common H subclades among Central Asians and have also been found in West Asia. '''H2a5''' has been found in the Basque Country, Spain, and in Norway+, Ireland+ and Slovakia+. '''H6a1a1a''' is common among Ashkenazi Jews.

These haplogroups are present in both Europe and West Asia, H13 being also found in the Caucasus. They are quite rare. '''H4''' is often found in Iberia+ and along with H13 and H2 account for 42% of H lineages in Egypt.

H11 is commonly found in Central Europe.

H18 occurs on the Arabian Peninsula.


These haplogroups are both found in the Caucasus region. H20 also appears at low levels in the Iberian Peninsula (less than 1%), Arabian Peninsula (1%) and Near East (2%).

These haplogroups are European / Near Eastern.


This phylogenetic tree of haplogroup H subclades is based on Build 16(February 2014) of the Phylotree, an internationally accepted standard. The full tree can be viewed at Phylotree.

! mtDNA HG "H" p-tree

*HV
**H
***H1
***H2
***H3
***H4
***H5'36
***H6
***H7
*** (T195C!)
****(T146C!)
*****H8
*****H31
****H11
****H12
****H91
***(T152C!)
****H9
****H32
****H46
****H52
****H69
***H10
***H13
***H14
***H15
***H16
***H18
***H20
***H21
***H22
***H23
***H24
***H25
***H26
***H28
***H29
***H30
***H33
***(C16291T)
****H34
****H64
****H85
***H35
***H39
***H40
***H41
***H42
***H43
***H44
***H45
***H47
***H48
***H49
***H50
***H51
***H53
***H54
***H55
***H56
***H57
***H58
***H59
***H60
***H61
***H62
***H63
***H65
***H66
***H67
***H70
***H71
***H72
***H73
***H74
***H75
***H76
***H77
***H78
***H79
***H80
***H81
***H82
***H83
***H84
***H85
***H86
***H87
***H88
***H89
***H90
***H92
***H93
***H94
***H95
***H96
***H100
|

Haplogroup H was found as a possible increased risk factor for ischemic cardiomyopathy development.

In his popular book ''The Seven Daughters of Eve+'', Bryan Sykes+ named the originator of this mtDNA haplogroup ''Helena''. Stephen Oppenheimer+ uses the very similar name ''Helina'' in his book The Origins of the British.

*Genealogical DNA test+
*Genetic genealogy+
*Human mitochondrial genetics+
*Population genetics+
*SNPedia+

mtDNA:

reflist:

*General
**Ian Logan's
**Mannis van Oven's
*Haplogroup H
** at Family Tree DNA+
**National Geographic's , from ''National Geographic+''
**mtDNA article at SNPedia+
**Amelia's
**
**Genebase's
**Genebase's
**Genebase's
**http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1274484/table/TB3/ Haplogroup and Subcluster Frequencies for European Populations
**
**
**
*Haplogroup H1
** The H1 mtDNA Haplogroup Project

 Haplogroup H (mtDNA)+ In human mitochondrial genetics, haplogroup H is a human mitochondrial DNA (mtDNA) haplogroup that likely originated in Southwest Asia 20,000-25,000 years before present.
 Haplogroup I (mtDNA)+ Haplogroup I is a human mitochondrial DNA (mtDNA) haplogroup. It is largely found in Northeast Africa, Europe and West Asia, the latter area which is believed to be the clade's place of origin.
 Haplogroup T (mtDNA)+ Haplogroup T is a human mitochondrial DNA (mtDNA) haplogroup. It is believed to have originated around 25,000 years ago in the Near East.
 Haplogroup U (mtDNA)+ Haplogroup U is a human mitochondrial DNA (mtDNA) haplogroup. Its subclades are widely distributed across Northern Europe, Eastern Europe, Central Asia, South Asia, North Africa, the Horn of Africa, and the Near East.
Haplogroup M (mtDNA)+ In human mitochondrial genetics, Haplogroup M is a human mitochondrial DNA (mtDNA) haplogroup. An enormous haplogroup spanning all the continents, the macro-haplogroup M, like its sibling N, is a descendant of haplogroup L3.
Haplogroup B (mtDNA)+ In human mitochondrial genetics, haplogroup B is a human mitochondrial DNA (mtDNA) haplogroup.
Haplogroup X (mtDNA)+ In human mitochondrial genetics, Haplogroup X is a human mitochondrial DNA (mtDNA) haplogroup found in Native Americans, Europeans, and Western Asians.
Haplogroup N (mtDNA)+ In human mitochondrial genetics, haplogroup N is a human mitochondrial DNA haplogroup . An enormous haplogroup spanning many continents, the macro-haplogroup N, like its sibling haplogroup M, is a descendant of haplogroup L3.
Haplogroup A (mtDNA)+ In human mitochondrial genetics, Haplogroup A is a human mitochondrial DNA (mtDNA) haplogroup.
Haplogroup R (mtDNA)+ Haplogroup R is a widely distributed human mitochondrial DNA (mtDNA) haplogroup. It is the most common macro-haplogroup in West Eurasia.